MUTEINS OF HUMAN NEUTROPHIL GELATINASE-ASSOCIATED

专利名称：MUTEINS OF HUMAN NEUTROPHIL

GELATINASE-ASSOCIATED LIPOCALIN ANDRELATED PROTEINS

发明人：SKERRA, Arne,SCHLEHUBER, Steffen申请号：EP02772321.2申请日：20020918公开号：EP1430131A2公开日：20040623

摘要：Disclosed is a method for generating a mutein of a protein selected from thegroup consisting of human neutrophil gelatinase-associated lipocalin (hNGAL), rat alpha2- microglobulin-related protein (A2m) and mouse 24p3/uterocalin (24p3), said muteinhaving detectable affinity to a given target. The method comprises the step of subjectingthe protein to mutagenesis at one or more of the sequence positions which correspondto the sequence positions 33 to , 66 to 83, 94 to 106, and 123 to 136 of hNGAL,resulting in one or more mutein(s) of the protein. Also disclosed are muteins obtainableby this method.

申请人：Pieris ProteoLab AG

地址：Lise-Meitner-Strasse 30 853 Freising DE

国籍：DE

代理机构：Viering, Jentschura & Partner

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